足细胞是一种高度特异的终末分化的上皮细胞,与肾小球基底膜和毛细血管内皮细胞共同构成肾小球滤过膜。很多肾小球疾病都存在着足细胞的损伤。最近的研究发现,足细胞存在一种抑制素依赖性的内吞作用,而特定的短片段干扰RNA(siRNA)又可以特异性的调节足细胞的基因表达。因此,通过激活足细胞的内吞机制,建立一种siRNA的定向 Podocyte is a highly specific terminally differentiated epithelial cells that together with the glomerular basement membrane and capillary endothelial cells make up the glomerular filtration membrane. Many glomerular diseases have podocyte damage. Recent studies have found that podocytes have a statin-dependent endocytosis and that specific short interfering RNAs (siRNAs) can specifically regulate podocyte gene expression. Therefore, by activating the endocytosis mechanism of podocytes, an orientation of siRNA is established