目的:制备积雪草总苷缓释片,并进行体外释放特性研究。方法:采用正交设计试验,以积雪草总苷的缓释性为评价指标,优化缓释片的制备工艺,并进行体外释放度试验。结果:所制备的缓释片的释放符合Higuchi方程,具有缓释制剂的体外溶出特征。结论:该方法制得的缓释片具有良好的缓释效果,且制备工艺简单易行。 OBJECTIVE: To prepare total glycosides of Centella asiatica sustained release tablets and study its in vitro release characteristics. Methods: The orthogonal test was used to evaluate the sustained release of the total glycosides of Centella asiatica. The preparation technology of sustained release tablets was optimized and the in vitro release test was carried out. Results: The release of the prepared sustained-release tablets conformed to the Higuchi equation with the in vitro dissolution profile of the sustained-release preparation. Conclusion: The sustained-release tablets prepared by the method have good sustained-release effect and the preparation process is simple and easy.