慢性粒-单型白血病(CMML)的临床特征为病程长,对化疗不敏感。以前对该病的皮肤浸润未进行过系统研究。作者见到4例有皮肤浸润的CMML患者,对其进行了较详细的研究。3例的皮肤浸润为红斑丘疹,1例为隆起的紫癜。活检表明所有皮肤损害均为单核样细胞浸润。患者出现皮肤浸润时,血及骨髓的白血病细胞的细胞化学、酯酶染色及膜表面标记研究均具有CMML的特征(苏丹黑染色阳性,Schiff过碘酸染色阳性及复合酯酶染色阳性等)。染色体分析核型正常,无Ph~1染色体。病例4在皮肤浸润出现后1个月,发生急性变。全部病例出现皮肤浸润后的存活时间为1.1-2.5月。4例均进行了化疗。虽然周围血白细胞数显著减少,但皮肤浸润并不见改善。例4的皮肤浸润特别广泛,周围血白细胞数迅速增加。由 The clinical features of chronic myelomonocytic leukemia (CMML) are long course and are not sensitive to chemotherapy. The skin infiltration of the disease before the system has not been studied. The authors met with 4 cases of CMML with skin infiltrate and conducted a more detailed study. 3 cases of skin infiltration of erythema papules, 1 case of elevated purpura. Biopsy showed that all skin lesions were mononuclear cell infiltrates. Cytochemistry, esterase staining and membrane surface labeling studies of leukemia cells in blood and bone marrow showed characteristic of CMML (positive for Sudan black staining, positive Schiff acid staining and complex esterase staining, etc.) in patients with skin infiltration. Chromosome analysis normal karyotype, no Ph ~ 1 chromosome. Case 4 Acute changes occurred 1 month after the skin infiltrates. All cases of skin infiltration after the survival time of 1.1-2.5 months. All 4 patients underwent chemotherapy. Although the number of peripheral blood leukocytes significantly decreased, but the skin infiltration did not improve. Example 4, the skin infiltration is particularly extensive, the number of peripheral white blood cells increased rapidly. by