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目的:分析术前外周血血钙水平和中性粒细胞淋巴细胞计数比(NLR)对肾癌预后判断的价值。方法:回顾2011全年经手术治疗的173例肾透明细胞癌患者的临床资料,分析影响肾透明细胞癌患者预后的相关因素,并在此基础上比较血钙下降组和正常组患者的生存情况。结果:单因素分析显示,术前血钙水平、NLR、术后肿瘤TNM分期及Furhman核分级是影响肾透明癌患者生存期的影响因素(均P<0.05);但多因素Cox回归分析提示,只有术后TNM分期和Furhman核分级为肾癌预后独立影响因素。进一步对血钙进行Kaplan-Meier生存曲线分析显示,下降组与正常组3年生存率分别为73.2%和93.6%,两组间差异有统计学意义(P<0.01)。结论:术前血钙水平和NLR可作为肾透明细胞癌预后的有效指标。
Objective: To analyze the value of preoperative serum calcium level and neutrophil lymphocyte count ratio (NLR) in the prognosis of renal cell carcinoma. Methods: The clinical data of 173 patients with renal clear cell carcinoma who underwent surgery in 2011 were retrospectively analyzed, and the related factors affecting the prognosis of renal clear cell carcinoma were analyzed. On the basis of these, the survival of patients with serum calcium decreased and normal group were compared . Results: Univariate analysis showed that preoperative serum calcium level, NLR, postoperative tumor TNM stage and Furhman’s nuclear grade were the influencing factors of survival time of patients with renal clear carcinoma (all P <0.05). However, multivariate Cox regression analysis showed that, Only postoperative TNM staging and Furhman nuclear classification were independent prognostic factors of renal cell carcinoma. Further analysis of Kaplan-Meier survival curves showed that the 3-year survival rates of the descending and normal groups were 73.2% and 93.6% respectively, with significant difference between the two groups (P <0.01). Conclusions: Preoperative serum calcium level and NLR can be used as effective indicators of the prognosis of renal clear cell carcinoma.