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We are pleased to present a Special Column on“Drug-and Chemical-induced Liver Injury”.The scope of articles in this issue is diverse,covering a wide range of unanswered questions in this research area faced by both clinicians and basic researchers.Liver i
【机 构】
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Department of Pathobiology and Diagnostic Investigation,Michigan State University,East Lansing,MI 48
论文部分内容阅读
We are pleased to present a Special Column on“Drug-and Chemical-induced Liver Injury”.The scope of articles in this issue is diverse,covering a wide range of unanswered questions in this research area faced by both clinicians and basic researchers.Liver injury remains a major obstacle in the development of new drugs and is a concern for otherwise incredibly efficacious drugs.Even for well-established hepatotoxic drugs,there continue to be landmark discoveries of new mechanisms.Likewise,a range of persistent environmental and industrial chemicals are associated with hepatic injury and the potential for environmental exposure to exacerbate chronic liver diseases should not be underestimated.Given these critical challenges,diverse articles in this special issue highlight novel findings at this nexus of multiple fields,including hepatology,toxicology,drug discovery,and human medicine.
其他文献
Acute lung injury(ALI)and its severe form acute respiratory distress syndrome(ARDS)are known as the common causes of respiratory failure in critically ill patients.Myeloid differentiation 2(MD2),a co-receptor of toll like receptor 4(TLR4),plays an importa
目的:观察荭草苷通过Notch通路对心律失常大鼠的改善作用及对心电图(ECG)的影响.方法:采用舌下注射乌头碱方式建立心律失常大鼠模型,随机分为模型组、荭草苷低剂量组(0.75 mg· kg-1)、荭草苷中剂量组(1.5 mg·kg-1)、荭草苷高剂量组(3 mg·kg-1),另设对照组.干预后监测ECG,比较心率(HR)、Q-T间期、P-R间期、QRS波群时间及室性早搏(PVC)、室性心动过速(VT)、心室颤动(VF)发生时间;HE染色观察心肌组织病理学变化;TUNEL染色观察心肌细胞凋亡情况;比较心肌
Emerging evidence shows that chronic inflammation mediated by toll-like receptors(TLRs)contributes to diabetic nephropathy.Myeloid differentiation primary-response protein-88(MyD88)is an essential adapter protein of all TLRs except TLR3 in innate immunity
Vascular calcification(VC)is characterized by pathological depositions of calcium and phosphate in the arteries and veins via an active cell-regulated process,in which vascular smooth muscle cells(VSMCs)transform into osteoblast/chondrocyte-like cells as
目的:建立以土大黄苷为标志性成分的保健食品中非法添加伪品大黄及其提取物的UPLC-QTRAP-MS/MS的分析方法.方法:样品用甲醇经超声提取,经Agilent InfinityLab Poroshell 120 SB-Cl8色谱柱(100mm×2.1 mm,2.7μm)分离,以5 mmol·L-1甲酸铵水溶液和乙腈作为流动相,进行梯度洗脱,在负离子扫描模式下,采用MRM-IDA-EPI模式检测.结果:土大黄苷质量浓度在5～100 ng·mL-1范围内线性均良好.相关系数(r2)为0.9987.土大黄苷在
Accumulating evidence indicates that mitochondrial dysfunction and oxidative stress play a pivotal role in the initiation and progression of nonalcoholic fatty liver disease(NAFLD).In this study,we found that blueberry-derived exosomes-like nanoparticles(
Transforming growth factor β(TGF-β)is a multifunctional polypeptide that plays critical roles in regulating a broad range of cellular functions and physiological processes.TGF-β signalling dysfunction contributes to many disorders,such as cardiovascular d
In recent years,fibroblast activation protein(FAP)has emerged as an attractive target for the diag-nosis and radiotherapy of cancers using FAP-specific radioligands.Herein,we aimed to design a novel 18F-labeled FAP tracer([18F]A1F-P-FAPI)for FAP imaging a
目的:探讨注射用头孢硫脒质量差异的来源及其与临床不良反应(adverse reaction,ADR)发生的关联性.方法:基于国家评价性抽验和不良反应数据,利用多变量数据分析方法(单因素方差分析、多重比较、相关性分析、线性拟合等),从常规质控项目(质量属性)和晶型(工艺属性)2个角度探讨该药物粉针产品间质量差异及其对临床安全性的影响.结果:注射用头孢硫脒所有质控项目中,仅杂质B和ADR严重报告数呈显著相关,且其差异主要来源于原料贮存和运输或制剂无菌分装过程.晶型与杂质B间拟合相关性最高(相关系数r=0.72
Ischemia/reperfusion(I/R)injury is a major cause of acute kidney injury(AKI)in clinic.The activation of NLRP3 inflammasome is associated with inflammation and renal injury in l/R-induced AKI.In the current study we explored the molecular and cellular mech