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目的探讨肠内营养应用于重症急性胰腺炎患者的疗效及改善营养状况的效果。方法采用随机平行对照法将2013年1月—2016年2月期间89例重症急性胰腺炎患者进行分组,对照组44例给予全胃肠外营养支持,观察组45例给予肠内营养支持,对比两组患者治疗后临床症状恢复时间、住院时间,与血清白蛋白、前白蛋白、血清淀粉酶、体质量改善效果,及并发症发生率。计数资料比较采用χ2检验,计量资料比较采用t检验,P<0.05认为差异具有统计学意义。结果观察组腹胀缓解时间、体温恢复时间、血尿淀粉酶恢复时间及住院时间[(5.59±2.03)d、(11.33±2.46)d、(15.93±2.61)d、(36.92±12.66)d],均低于对照组[(1.98±1.39)d、(7.49±1.82)d、(9.98±2.33)d、(19.93±7.11)d](均P<0.05);观察组治疗后血清白蛋白及前白蛋白高于对照组,血清淀粉酶低于对照组(均P<0.05);观察组体质量略高于对照组(P>0.05);观察组并发症发生率、死亡率(15.56%、0%)均低于对照组(59.09%、11.36%)(均P<0.05)。结论肠内营养能够显著改善重症急性胰腺炎患者的营养状况,缓解临床症状,提高生存率,安全性高,值得临床的推广及应用。
Objective To investigate the effect of enteral nutrition on patients with severe acute pancreatitis and to improve the nutritional status. Methods A total of 89 patients with severe acute pancreatitis were divided into two groups by randomized parallel control method from January 2013 to February 2016, 44 patients in the control group were given parenteral nutrition support, and 45 patients in the observation group were given enteral nutrition support. The recovery time of clinical symptoms, length of hospital stay, and serum albumin, prealbumin, serum amylase, improvement of body weight and complication rates after treatment in both groups were statistically significant. Counting data were compared using χ2 test, measurement data were compared using t test, P <0.05 that the difference was statistically significant. Results The abdominal distension time, body temperature recovery time, hematuria amylase recovery time and hospital stay in the observation group [(5.59 ± 2.03) d, (11.33 ± 2.46) d, (15.93 ± 2.61) d, (36.92 ± 12.66) d] Lower than the control group [(1.98 ± 1.39) d, (7.49 ± 1.82) d, (9.98 ± 2.33) d, (19.93 ± 7.11) d] (all P <0.05) (P <0.05). The body weight of the observation group was slightly higher than that of the control group (P> 0.05). The incidence of complications and death rate in the observation group (15.56%, 0% ) Were lower than the control group (59.09%, 11.36%) (all P <0.05). Conclusion Enteral nutrition can significantly improve the nutritional status of patients with severe acute pancreatitis, relieve clinical symptoms, improve survival, high safety, and worthy of clinical promotion and application.