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应用小鼠骨髓嗜多染红细胞微核试验，分别对从市售污染水果梨和桔子中分离出的优势真菌互隔交链孢霉和指状青霉提取物进行诱变实验。结果：菌株Ａ６和菌株Ｐ３提取物分别在达到２００ｍｇ／ｋｇ、１６０ｍｇ／ｋｇ时，其微核出现率分别为１６．８±０．３９‰、１８．２±０．３８‰，与溶剂对照组（ＤＭＳＯ）３．６０±０．４６‰相比有显著性差异（Ｐ＜０．０１），并呈明显的剂效关系。说明互隔交链孢霉和指状青霉两种提取物含有使染色体损伤的物质。
The micronucleus test of mouse bone marrow polychromatic erythrocytes was used to mutagenize the dominant fungi Alternaria alternata and Penicillium albopictus extracts isolated from commercially-contaminated fruit pears and oranges, respectively. Results: The micronuclei incidences of strains A6 and P3 were 16.8 ± 0.39 ‰ and 18.2 ± 0.38 ‰ at 200mg / kg and 160mg / kg, respectively. Compared with the solvent control group (DMSO) 3.60 ± 0.46 ‰ compared with significant difference (P <0.01), and showed a significant efficacy relationship. Description Both Alternaria alternata and Penicillium dichotoma two extracts contain substances that cause chromosomal damage.