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采用LKB-2277生物活性检测系统,测定了37℃时白色念珠菌在巴马汀作用下生长代谢的热谱曲线,并获得9个相应的定量热动力学参数,经主成分分析综合评价巴马汀的抗白色念珠菌作用.结果表明巴马汀的抗白色念珠菌作用主要受热谱曲线第二指数生长期的生长速率常数k_2和最大产热功率P_m~2的影响,通过分析这两个主要参数的数值变化,能更方便、快捷和准确地评价巴马汀的抗白色念珠菌作用,为进一步评价其它药物和化合物的抗菌作用提供了有用的方法和基础.
The thermogram of growth and metabolism of Candida albicans under the action of palmatine at 37 ℃ was determined by LKB-2277 bioassay system and nine corresponding quantitative thermodynamic parameters were obtained. Based on the principal component analysis, a comprehensive evaluation of Bama Candida albicans.The results showed that the effect of palmatine on Candida albicans was mainly influenced by the growth rate constant k_2 and the maximum heat production power P_m ~ 2 during the second exponential phase of the thermogram curve. By analyzing these two main The numerical changes of the parameters can be more convenient, fast and accurate evaluation of the role of palmatine against Candida albicans, to further evaluate the antibacterial effect of other drugs and compounds provide a useful method and foundation.