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本实验采用快速点燃大鼠模型，分析了在点燃后不同时间内大鼠大脑皮层、海马和小脑内脑啡肽、强啡肽含量的变化规律，以探讨内源性阿片肽在快速点燃的发生和发展过程中的作用。结果：点燃后即刻，大鼠大脑皮层，海马及小脑内脑啡肽含量明显升高，至第７ｄ回到对照水平；点燃后即刻大鼠大脑皮层内强啡肽含量明显升高，２ｄ后回至对照水平，但至点燃后第７ｄ再次升高；与大脑皮层不同，海马及小脑内强啡肽含量在点燃即刻有显著下降，点燃后２ｄ海马内强啡肽含量开始回升，至第７ｄ已明显高于点燃即刻水平，但仍低于对照水平；而小脑内强啡肽含量至点燃后７ｄ回升至即刻水平。上述结果提示：脑内脑啡肽的变化与快速点燃的发生有关，而强啡肽则可能参与了点燃的发生和发展过程，且在不同时间不同脑区强啡肽的作用可能不同
In this study, the rapid ignition rat model was used to analyze the changes of enkephalin and dynorphin in the cerebral cortex, hippocampus and cerebellum in different time after ignition in order to investigate the occurrence of endogenous opioid in rapid ignition And the role of development process. Results: Immediately after ignition, the content of enkephalin in the cerebral cortex, hippocampus and cerebellum of rats increased significantly, and returned to the control level on the 7th day. The content of dynorphin in the cerebral cortex of the rats immediately after ignition increased significantly, and after 2 days To the control level, but it increased again on the 7th day after lighting. Compared with the cerebral cortex, the content of dynorphin in the hippocampus and cerebellum decreased immediately after ignition, and the content of dynorphin in the hippocampus began to rise 2 days after ignition, Significantly higher than the immediate level of ignition, but still below the control level; and cerebrum content of dynorphin rose to the immediate level 7d after ignition. The above results suggest that the changes of enkephalin in the brain are related to the rapid ignition, while the dynorphin may be involved in the occurrence and development of ignition, and the effects of dynorphin in different brain regions may be different at different times