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目的研究血浆和脑脊液中IL-6、TNF-α水平与新生儿HIE的相关性。方法将120例中、重度新生儿HIE患儿随机分成常规治疗组和高压氧治疗组,60例相同时期住院的新生儿为对照组。常规治疗组给予暖箱保暖,保持呼吸道通畅,抗生素预防感染,营养脑细胞等对症支持治疗。高压氧治疗组在常规治疗组治疗方案的基础上加用高压氧治疗。选用ELISA法测试血浆和脑脊液中IL-6、TNF-α水平。结果常规治疗组与高压氧治疗组患儿血浆和脑脊液中IL-6、TNF-α水平明显高于对照组(P<0.05),经过治疗后均明显下降(P<0.05),高压氧治疗组下降更为显著。结论TNF-α和IL-6与新生儿HIE的发病、治疗相关。
Objective To study the correlation between IL-6 and TNF-α levels in plasma and cerebrospinal fluid (CSF) and neonatal HIE. Methods 120 cases of moderate and severe neonatal HIE were randomly divided into routine treatment group and hyperbaric oxygen treatment group, and 60 newborns hospitalized in the same period as the control group. The conventional treatment group was given warm box to keep the airway open, antibiotics to prevent infection, nutritional brain cells and other symptomatic and supportive treatment. Hyperbaric oxygen treatment group in the conventional treatment group based on the treatment program plus hyperbaric oxygen therapy. ELISA method was used to test the levels of IL-6 and TNF-α in plasma and cerebrospinal fluid. Results The levels of IL-6 and TNF-α in plasma and cerebrospinal fluid in the treatment group and the hyperbaric oxygen treatment group were significantly higher than those in the control group (P <0.05), and were significantly decreased after treatment (P <0.05) Decline is even more significant. Conclusion TNF-α and IL-6 are associated with the pathogenesis and treatment of neonatal HIE.