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本文报道1980年－1996年在湖沼型重流行区吡喹酮5种化疗策略控制日本血吸虫病的效果。结果：靶人群化疗后1个月、3个月粪检阴转率均在86％以上，扩大化疗3年粪检阳性率下降74.90％，群体化疗1次和每年1次、每年2次连续2年粪检阳性率分别下降54.36％和70.19％、75.51％，阶段化疗3年粪检阳性率下降88.34％，间歇性化疗粪检阳性率下降39.34％。并对吡喹酮群体与个体化疗的剂量与疗法、不同阶段不同化疗策略的合理应用、群体化疗的对象等进行了讨论。
This article reports the effect of five chemotherapy regimens of praziquantel in controlling schistosomiasis japonica from 1980 to 1996 in the heavy lakes and marshes in the lake. Results: After 1 month and 3 months after chemotherapy, the fecal negative conversion rates were over 86%. The positive rate of fecal seizures was 74.90% after 3 years of extended chemotherapy. The group chemotherapy was once and twice a year for 2 consecutive years. The positive rates of fecal seizures decreased by 54.36% and 70.19%, respectively, 75.51%. The positive rate of stool examination in the three-year phase of chemotherapy decreased by 88.34% and the positive rate of intermittent chemotherapy decreased by 39.34%. The dose and therapy of praziquantel groups and individual chemotherapy, rational application of different chemotherapy strategies in different stages, and the target of group chemotherapy were discussed.