论文部分内容阅读
目的对比分析不同疗程传统三联疗法与含左氧氟沙星三联疗法治疗幽门螺杆菌(HP)感染的效果。方法收集2015年10月至2016年6月,经~(14)C呼气试验(~(14)C-UBT)检测,HP感染阳性的患者229例,随机分为RCA-7d组、RCA-14 d组、RCL-7 d组与RCL-14 d组,四组均服用雷贝拉唑20 mg bid,克拉霉素0.5 g bid,其中RCA-7 d组与RCA-14 d组加用阿莫西林1 g bid,疗程分别为7与14 d;RCL-7 d组与RCL-14 d组加用左氧氟沙星0.2 g bid,疗程分别为7与14 d。对比两种方法、不同疗程,其HP根除率及不良反应发生率。结果 RCA-7 d组、RCA-14 d组、RCL-7 d组与RCL-14 d组的HP根除率分别为69.0%、84.2%、50.8%与61.8%;在相同疗程、不同方法中,RCA-7 d组与RCL-7 d组、RCA-14 d组与RCL-14 d组,两者HP根除率比较差异有统计学意义(P<0.05);在相同方法、不同疗程中,RCA-7 d组与RCA-14 d组、RCL-7 d组与RCL-14 d组,两者HP根除率比较差异无统计学意义(P>0.05)。RCA-7 d组、RCA-14 d组、RCL-7 d组与RCL-14 d组的不良反应发生率分别为10.3%、15.8%、6.8%和12.7%,无论两种方法,还是两种疗程,比较差异无统计学意义(P>0.05)。结论传统三联疗法相对于含左氧氟沙星三联疗法,HP根除率高、不良反应少,仍可考虑选用。14 d疗程相对7 d疗程,不良反应虽无显著增加,但也不能显著提高HP根除率,不建议通过延长疗程提高根除率。
Objective To compare and analyze the effect of traditional triple therapy with levofloxacin triple therapy on Helicobacter pylori (HP) infection in different courses. Methods Totally 229 patients with positive HP infection who were tested by ~ (14) C breath test (~ (14) C-UBT) from October 2015 to June 2016 were randomly divided into RCA-7d group, RCA- 14 d group, RCL-7 d group and RCL-14 d group. Rabeprazole 20 mg bid and clarithromycin 0.5 g bid were administered to the four groups, with RCA-7 d group and RCA-14 d group In the RCL-7 group and the RCL-14 group, levofloxacin was administered 0.2 g bid for 7 and 14 days, respectively. Comparing the two methods, different courses, the HP eradication rate and the incidence of adverse reactions. Results The eradication rates of HP in RCA-7 d group, RCA-14 d group, RCL-7 d group and RCL-14 d group were 69.0%, 84.2%, 50.8% and 61.8% respectively. In the same course and different methods, RCA-7 d group and RCL-7 d group, RCA-14 d group and RCL-14 d group, the difference of HP eradication rate was statistically significant (P <0.05); in the same method and different courses of treatment, RCA There was no significant difference in the eradication rates of HP between the group of -7 d and the group of RCA-14 d, the group of RCL-7 d and the group of RCL-14 d (P> 0.05). The rates of adverse reactions in RCA-7 d, RCA-14 d, RCL-7 d and RCL-14 d groups were 10.3%, 15.8%, 6.8% and 12.7%, respectively, regardless of the two methods Treatment, the difference was not statistically significant (P> 0.05). Conclusion Traditional triple therapy compared with levofloxacin triple therapy, HP eradication rate, fewer adverse reactions, can still be considered. 14 d course of treatment relative to 7 d, although no significant increase in adverse reactions, but it can not significantly improve the HP eradication rate, does not recommend prolonged treatment by raising the eradication rate.