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本实验运用体内体外结合检测环境诱变物/致癌物方法,测试了从林县粮食中分离的互隔交链孢霉两菌株提取物261—B_2—3和C_(12)b3—2的诱变性。结果显示,两株提取物能直接诱发人外周血淋巴细胞SCE频率升高及染色体畸变,与对照组比较差差异极显著(P<0.01)。经小鼠体内代谢后,这两株提取物仍能诱发细胞SCE频率升高。说明两株提取物经小鼠体内代谢前后均具有诱变活性。本文还叙述和讨论了体内体外结合检测方法的优缺点。
In this experiment, the mutagenicity of 261—B_2-3 and C_(12)b3—2 extracts of Alternaria alternans isolated from Linxian grain was tested by in vitro and in vivo detection of environmental mutagens/carcinogens. transsexual. The results showed that the two extracts could directly induce the increase of SCE frequency and chromosomal aberrations in human peripheral blood lymphocytes, and there was a significant difference compared with the control group (P<0.01). After being metabolized in mice, the two extracts can still induce the increase of SCE frequency in cells. It showed that both extracts had mutagenic activity before and after metabolism in mice. This article also describes and discusses the advantages and disadvantages of in vitro and in vivo binding assays.