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目的探讨柴胡皂苷a(SSa)对匹罗卡品致难治性癫痫模型大鼠痫性发作的影响。方法将制备成功的48只SD难治性癫痫大鼠模型随机分为模型组(B)、丙戊酸钠组(C)、柴胡皂苷a低剂量组(D)和高剂量组(E)4组,每组各12只,另有空白对照组(A)12只。A、B组给予等量生理盐水,C组用量为200mg/kg,D、E组用药浓度依次为1.09mg/kg、2.18mg/kg,A、B、C组灌胃给药,D、E组腹腔注射给药。分别观察给药4周、8周后痫性发作次数、平均发作时间及发作级别的变化。结果痫性发作方面,A组无痫性发作,B组大鼠痫性发作明显(P>0.05),C、D、E组大鼠痫性发作均有不同程度的减轻(P<0.05),E组大鼠痫性发作减轻最明显。结论柴胡皂苷a能减轻难治性癫痫大鼠的痫性发作,有明显的抗癫痫作用。
Objective To investigate the effects of saikosaponin a (SSa) on the seizure in rats with intractable epilepsy induced by pilocarpine. Methods Forty eight SD rats with intractable epilepsy were randomly divided into model group (B), sodium valproate group (C), low dose group of Saikosaponin (A) and high dose group (E) 4 groups, 12 in each group, and 12 in the blank control group (A). The rats in group A and B were given the same amount of normal saline, the dosage of C was 200mg / kg, the dosage of D and E were 1.09mg / kg and 2.18mg / kg, Group intraperitoneal injection. The changes of seizure frequency, average seizure time and seizure level were observed after 4 weeks and 8 weeks respectively. Results In epileptic seizures, there was no seizure in group A, seizure was significant in group B (P> 0.05), and epileptic seizures in groups C, D and E were relieved to some extent (P <0.05) E group rats seizures reduce the most obvious. Conclusion Saikai saponin a can reduce epileptic seizures in patients with intractable epilepsy, with obvious antiepileptic effect.