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目的观察雷公藤多甙对实验性自身免疫性脑脊髓炎(EAE)大鼠脊髓中β-APP和IL-17表达的影响。方法将30只大鼠随机分为空白对照组(CON组)、模型组(EAE组)、治疗组(TWP组),建模后分别行神经功能评分,大鼠脊髓组织行HE染色,免疫组化检测脊髓中β-APP和IL-17表达水平。结果与EAE组比较,TWP组大鼠发病率下降,平均神经功能评分降低,炎性细胞浸润减少,在神经功能评分和病理学改变方面差异明显(P<0.05);免疫组化示TWP组较EAE组β-APP和IL-17表达水平降低(P<0.05)。结论雷公藤多甙对EAE大鼠有一定保护作用,可能与抑制β-APP、IL-17表达有关。
Objective To observe the effect of tripterygium wilfordii polyglycosidium on the expression of β-APP and IL-17 in spinal cord of experimental autoimmune encephalomyelitis (EAE) rats. Methods Thirty rats were randomly divided into control group (CON group), model group (EAE group) and treatment group (TWP group). Neurological function scores were obtained after spinal cord injury. The levels of β-APP and IL-17 in the spinal cord were measured. Results Compared with EAE group, the incidence of TWP rats decreased, mean nerve function score decreased, inflammatory cell infiltration decreased significantly in neurological function score and pathological changes (P <0.05) The levels of β-APP and IL-17 in EAE group decreased (P <0.05). Conclusion Tripterygium glycosides have certain protective effect on EAE rats, which may be related to the inhibition of the expression of β-APP and IL-17.