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年龄40～75岁的1395例心绞痛患者(其中809例确定为心肌梗塞,162例可能为心肌梗塞)用美多心安进行双盲试验。住院后尽早静脉内给予美多心安15毫克,以后每日给200毫克共三个月。安慰剂按同样方式给予。在急性期,心绞痛的严重程度按所记录的给予止痛剂注射次数及疼痛持续时间进行计算。接受美多心安的患者,在头四天期间的止痛剂平均注射次数要比用安慰剂者的少,而且疼痛时间较短。这些效应也与用药前的心率和收缩压,以及根据心电图测定的最终梗塞部位有关。因此,疑似或肯定为心肌梗塞时,在急性期给予美多心安可减轻心绞痛的严重程度。
A total of 1395 patients with angina pectoris aged 40-75 years (809 of whom were identified as MI and 162 as MI) underwent double-blind trials with metoprolol. As soon as possible after admission to the United States and more peace of mind 15 mg, 200 mg daily for a total of three months. Placebo is given in the same way. In the acute phase, the severity of angina is calculated on the basis of the number of analgesic injections given and duration of pain recorded. The patients who received DTPA had a lower average number of injections of painkillers during the first four days than those who took placebo and had a shorter painful time. These effects are also related to the heart rate and systolic blood pressure before treatment, as well as the final infarct location determined by the electrocardiogram. Therefore, the suspected or certainly myocardial infarction, in the acute phase of metoprolol can reduce the severity of angina.