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肿瘤细胞有非随机的染色体异常,这是肿瘤细胞遗传学研究最有创见的结论之一。近来还认识到细胞癌基因的激活是导致某些肿瘤的通常途径。已有人强调指出,在一些癌断裂点和癌基因之间存在着联系。本文收集文献、作者实验室和其他同事提供的资料,综合分析了5345例采用显带研究的肿瘤病例,试图了解癌断裂点和癌基因相关的程度有多大。上述病例不包括以Ph染色体为唯一异常的慢性粒细胞性白血病,且均只有一个结构畸变。为了减少核型解释上可能发生的错误,要求该种结构畸变至少见于2例相同或密切相关的肿瘤。26个细胞癌基因定位于特定带的资料系从文献中获得。结果在5 345例肿瘤中共检出77种不同
There are non-random chromosomal abnormalities in tumor cells, which is one of the most invasive conclusions in the study of tumor cell genetics. It has also recently been realized that the activation of cellular oncogenes is the usual route leading to certain tumors. It has been emphasized that there is a link between some cancer breakpoints and oncogenes. This article collects data from the literature, the author’s laboratory, and other colleagues, and comprehensively analyzes 5345 cases of tumors that used the banding study to try to understand how large the cancer breakpoints are related to oncogenes. The above cases did not include chronic myelocytic leukemia with the only abnormal Ph chromosome, and all had only one structural aberration. In order to reduce the possible errors in karyotype interpretation, it is required that the structural distortion be seen in at least two identical or closely related tumors. The data of 26 cell oncogenes located in specific bands was obtained from the literature. Results A total of 77 different cases were detected in 5 345 tumors