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目的探讨预防糖耐量异常(IGT)人群发展为2型糖尿病(T2DM)的有效方法,降低T2DM发生的危险性。方法对226例IGT人群分两组采用单纯生活方式干预及生活方式加药物干预,观察两组人群T2DM发病情况的差异。结果治疗组(生活方式加药物干预组)和对照组(单纯生活方式干预组)治疗6个月后,治疗组空腹血糖(FPG)、葡萄糖耐量试验后2h血糖均明显下降,且与对照组比较差异有统计学意义。结论应用生活方式加药物(拜糖平)干预IGT发展为T2DM明显强于单纯生活方式干预。
Objective To explore an effective way to prevent the development of type 2 diabetes mellitus (T2DM) in people with impaired glucose tolerance (IGT) and to reduce the risk of T2DM. Methods Two hundred and twenty-six IGT patients were divided into two groups using simple lifestyle interventions and lifestyle interventions to observe the differences in the incidence of T2DM among the two groups. Results After treatment for 6 months in treatment group (lifestyle plus drug intervention group) and control group (lifestyle intervention group), fasting blood glucose (FPG) and blood glucose 2h after glucose tolerance test in treatment group decreased significantly compared with control group The difference was statistically significant. Conclusion The lifestyle and medication intervention (IGS) intervention for IGT is significantly better than simple lifestyle intervention for T2DM.