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目的:探讨脉压、收缩压、舒张压水平与颈动脉粥样硬化(CAS)狭窄程度的关系。方法:对80例入选病例均行彩色多普勒超声测定颈总动脉内中膜厚度及斑块积分,根据颈动脉超声结果将患者分为斑块组、非斑块组,测量中心及外周收缩压、舒张压及脉压,应用统计学方法评定其与CAS的关系。结果:斑块组脉压显著高于非斑块组(P<0.01),CAS发生率在脉压≥50mmHg(1mmHg=0.133kPa)患者显著高于脉压<50mmHg患者(P<0.01),多元线性回归分析表明脉压是CAS发生发展的独立危险因素,且中心脉压较肱动脉脉压预测心血管事件的危险性更好。结论:中心脉压可作为CAS狭窄程度的高危预测指标之一。
Objective: To investigate the relationship between pulse pressure, systolic pressure, diastolic blood pressure and carotid atherosclerosis (CAS) stenosis. Methods: The carotid artery intima-media thickness and plaque score were measured in 80 selected cases by color Doppler ultrasound. The patients were divided into plaque group, non-plaque group, measurement center and peripheral constriction Pressure, diastolic pressure and pulse pressure, the relationship between CAS and CAS should be evaluated by statistical methods. Results: The pulse pressure of plaque group was significantly higher than that of non-plaque group (P <0.01). The incidence of CAS in patients with pulse pressure ≥50mmHg (1mmHg = 0.133kPa) was significantly higher than that of patients with pulse pressure <50mmHg (P <0.01) Linear regression analysis showed that pulse pressure was an independent risk factor for the development of CAS, and the risk of cardiovascular events was better than that of brachial artery pulse pressure. Conclusion: Central pulse pressure can be used as one of the high risk predictors of CAS stenosis.