国产血卟啉衍生物HA-308(扬州生化制药厂制备)在小鼠肿瘤组织中能产生红色荧光,照射激光后可杀死肿瘤细胞,其光敏作用与国外报道的卟啉类光敏药物相似。我们对其作了有效成分的分离和鉴定。高效液相色谱分析表明,其中含量较高的成分有8种,此外尚有若干微量成分。在生物凝胶柱上,本品呈 Domestic hematoporphyrin derivative HA-308 (prepared by Yangzhou Biochemical Pharmaceutical Factory) can produce red fluorescence in mouse tumor tissues, and can kill tumor cells after irradiation, and its photosensitivity is similar to that reported abroad for porphyrin photosensitizer drugs. We separated and identified the active ingredients. High-performance liquid chromatography analysis showed that there are 8 kinds of components in which the content is relatively high, and there are still a few trace components. On the biogel column, this product was presented