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目的探讨在控制性超促排卵(COH)中coasting疗法与体外受精-胚胎移植(IVF-ET)治疗结局的关系。方法对南方医科大学南方医院生殖医学中心2005年1月至2005年12月222例不孕症患者的临床资料进行回顾性分析。根据是否行coasting疗法分为两组,比较两组的卵泡数、卵子数、临床妊娠率、种植率和分娩率。结果coasting组的coasting天数为(1.3±0.5)d,coasting组与非coasting组的卵泡数、卵子数分别为(33.0±7.6)个、(17.1±7.1)个和(17.4±7.7)个、(11.9±4.8)个,coasting组显著高于非coasting组,差异有显著性意义(P<0.05),而临床妊娠率、种植率和分娩率分别为51.4%、34.6%、48.6%和47.8%、28.8%、44.0%,差异无显著性意义(P>0.05)。结论coasting是预防重度卵巢过度刺激综合征(OHSS)的一种有效方法,不影响IVF-ET的妊娠结局。
Objective To investigate the relationship between coasting therapy and in vitro fertilization-embryo transfer (IVF-ET) outcome in controlled ovarian hyperstimulation (COH). Methods The clinical data of 222 infertility patients from January 2005 to December 2005 in Reproductive Medicine Center of Nanfang Hospital of Southern Medical University were retrospectively analyzed. According to whether the coasting therapy is divided into two groups, the number of follicles, egg count, clinical pregnancy rate, implantation rate and delivery rate were compared between the two groups. Results The number of coasting days in the coasting group was (1.3 ± 0.5) d. The numbers of oocytes and follicles in the coasting and non-coasting groups were (33.0 ± 7.6), (17.1 ± 7.1) and (17.4 ± 7.7), respectively 11.9 ± 4.8). The rates of clinical pregnancy, implantation and delivery were 51.4%, 34.6%, 48.6% and 47.8%, respectively, in the coasting group was significantly higher than that in the non-coasting group (P <0.05) 28.8%, 44.0%, the difference was not significant (P> 0.05). Conclusion Coasting is an effective method to prevent severe ovarian hyperstimulation syndrome (OHSS) and does not affect the pregnancy outcome of IVF-ET.