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探讨血管扩张剂对蛛网膜下腔出血后迟发性脑血管痉挛（ＤＣＶＳ）时痉挛动脉的扩张作用。方法使用２次经枕骨大孔注入新鲜自体动脉血致ＤＣＶＳ狗的动物模型，ＤＣＶＳ组８只狗，对照组８只狗。将尼莫地平配制成１０－６ｍｏｌ／Ｌ浓度，罂粟碱配制成１０－４ｍｏｌ／Ｌ浓度，将两种不同的血管扩张药物直接应用于正常和ＤＣＶＳ狗动物模型的基底动脉上。通过显微摄像系统动态观察两种药物对正常及ＤＣＶＳ时痉挛动脉的直接作用。结果尼莫地平与罂粟碱对正常狗的基底动脉都有明显的扩张作用（Ｑ值＝１９．２７４４，Ｐ＜０．０１），但尼莫地平对ＤＣＶＳ狗的痉挛动脉无扩张作用，罂粟碱对痉挛动脉有轻度扩张作用。结论提示尼莫地平是通过扩张非痉挛动脉来改善脑血流量的。罂粟碱对非痉挛与痉挛动脉都有扩张作用，但其扩张血管作用的时效短。
To investigate the dilation effect of vasodilators on arterial dilatation of spasticity in patients with delayed cerebral vasospasm (DCVS) after subarachnoid hemorrhage. Methods Two animal models of DCVS dogs injected with fresh autologous arterial blood via the foramen magnum were used. Eight dogs in the DCVS group and eight dogs in the control group. Nimodipine was formulated at a concentration of 10-6 mol / L and papaverine was formulated at a concentration of 10-4 mol / L. Two different vasodilators were directly applied to the basilar artery of normal and DCVS dog animal models. The direct effects of the two drugs on the arteries of the spasticity in normal and DCVS were observed dynamically by microscopic camera system. Results Nimodipine and papaverine had significant dilatation effects on the basilar artery of normal dogs (Q = 19.2744, P <0.01). However, nimodipine did not dilate the spastic arteries of DCVS dogs. Papaverine Spasm artery mild dilatation effect. The conclusion suggests that nimodipine improves cerebral blood flow by expanding the non-convulsive artery. Papaver’s spasm on the non-spasm and spasm arteries have expansion, but its short-term dilation of blood vessels.