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目的探讨唐氏综合征发生的影响因素,为制定预防措施提供科学依据。方法选择徐州市儿童医院病理科2013年1月至2014年12月经染色体检查确诊的唐氏综合征患儿为病例组,选取同一医院同期就诊的正常婴幼儿为对照组,对2组儿童的父母进行问卷调查。结果多因素Logistic回归分析发现,母亲育龄(≥35岁)(OR=5.078)、孕前发热(OR=3.280)、接触农药(OR=12.648)、周边环境污染(OR=4.865)、家庭装修或购买新车(OR=3.485)、补充叶酸(OR=0.460)、美甲(OR=8.627)、过度疲劳(OR=3.598)为唐氏综合征发生的影响因素。结论唐氏综合征的发生受到多种因素的影响,母亲育龄(≥35岁),孕前发热、接触农药、周边环境污染、家庭装修或购买新车、美甲、过度疲劳是唐氏综合征发生的危险因素,补充叶酸是唐氏综合征的保护因素。
Objective To investigate the influencing factors of Down Syndrome and provide a scientific basis for making preventive measures. Methods The children with Down syndrome diagnosed by chromosomal examination from January 2013 to December 2014 in Xuzhou Children’s Hospital were selected as the case group. The normal infants treated in the same hospital at the same period were selected as the control group. The parents of the two groups of children Questionnaire. Results The multivariate Logistic regression analysis showed that maternal age (≥35 years) (OR = 5.078), pre-pregnancy fever (OR = 3.280), pesticide exposure (OR = 12.648), peripheral environmental pollution New car (OR = 3.485), folic acid supplementation (OR = 0.460), manicure (OR = 8.627) and over fatigue (OR = 3.598) were the influencing factors in Down Syndrome. Conclusion The occurrence of Down Syndrome is affected by many factors, such as mother’s childbearing age (≥35years old), fever before pregnancy, pesticide exposure, surrounding environment pollution, family decoration or buying a new car, manicure and excessive fatigue is the risk of Down’s syndrome Factors, folic acid supplementation is a protective factor in Down Syndrome.