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目的 探讨蛛网膜下腔出血(SAH)对皮质神经元的损伤及其机制,为临床脑保护提供有效的治疗方法。方法 将40只大耳白兔随机分为5组:A组(空白对照组)、B组、C组、D组、E组(实验组)。脑池内血液注入法制作SAH模型。对A组动物脑枕大池内注入生理盐水,对B、C、D、E组动物注入自体鲜血。分别于术后1d(B组)、3d(C组)、5d(D组)及7d(E组)处死动物,取颞叶的大脑皮质行光镜观察及用凋亡细胞原位末端标记技术对神经细胞进行检测。结果 实验组动物均可检测出凋亡细胞,B组神经细胞凋亡指数低于C组、D组、E组(P<0.05)。结论 SAH后出现迟发性神经元死亡(DND),凋亡在DND中起重要的作用。
Objective To investigate the effects of subarachnoid hemorrhage (SAH) on cortical neurons and its mechanism, and to provide an effective treatment for clinical brain protection. Methods Forty white rabbits were randomly divided into five groups: group A (blank control group), group B, group C, group D and group E (experimental group). SAH model was made by intracisternal injection of blood. A group of animal brain pillow into the pool of saline, B, C, D, E group of animals injected with blood. The animals were sacrificed at 1 day (group B), 3d (group C), 5 days (group D) and 7 days (group E) respectively. The temporal lobe cortex was observed with light microscope and in situ terminal labeling Nerve cells are tested. Results Apoptotic cells were detected in all experimental groups. The apoptosis index of neurons in group B was lower than that in group C, D and E (P <0.05). Conclusions Delayed neuronal death (DND) occurs after SAH, and apoptosis plays an important role in DND.