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应用放射免疫分析方法,测定了16只哮喘豚鼠下呼吸道各部和循环血液中神经激肽A(NKA)的水平,与健康对照组(气管含量为44.56±20.86,支气管53.78±32.12,左肺上叶63.15±20.52Pg/g,血液81.49±32.56pg/ml,(?)±SD)相比,哮喘豚鼠下呼吸道和血液中NKA的水平(气管59.90±19.36 P<0.05,支气管70.51±16.60 P<0.05,左肺上叶78.83±19.08Pg/g P<0.05,血液119.37±16.24pg/ml P<0.001,(?)±SD)显著升高。结果提示,NKA可能参与哮喘发作的病理生理过程,可能是其发作的因素之一。
Radioimmunoassay was used to determine the levels of neurokinin A (NKA) in the lower respiratory tract and circulating blood of 16 asthmatic guinea pigs. Compared with healthy control group (tracheal content 44.56 ± 20.86, bronchus 53.78 ± 32.12, left upper lobe The levels of NKA in the lower respiratory tract and blood of asthmatic guinea pigs (59.90 ± 19.36 P <0.05 for trachea and 70.51 ± 16.60 P <0.05 for bronchial asthma) were significantly lower in asthmatic guinea pigs than those in controls (63.15 ± 20.52 pg / g, 81.49 ± 32.56 pg / ml in blood, , 78.83 ± 19.08 pg / g P <0.05 in the left upper lobe, and 119.37 ± 16.24 pg / ml in the blood, P <0.001, (±) SD). The results suggest that NKA may be involved in the pathophysiology of asthma attacks may be one of the factors of its attack.