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为探讨巨细胞病毒（ＣＭＶ）感染所致婴儿肝损害的频率及转归，对４７例血清抗ＣＭＶＩｇＧ阳性母亲所生婴儿于生后２周内、１、３、６、１２月龄定期随访，应用ＥＬＩＳＡ法监测皿清抗ＣＭＶＩｇＭ和ＩｇＧ、尿ＣＭＶＤＮＡ（应用原位杂交法）和动态观察肝脏病变；并除外胆道系统畸形、代谢性肝病、药物中毒性肝炎和甲、乙、丙型肝炎。结果表明，至周岁时４０例婴儿感染ＣＭＶ。其中５２．５％（２１／４０）有肝脏受累。先天和围生期感染组肝损害发生率为７５．０％（１８／２４），较生后感染组（３ｌ１６，１８．８％）明显为高，而未感染儿未见肝损害。除４例为显性肝炎外，多表现为亚临床型。近半数病例（１０／２１）伴脾肿大。周岁时随访除１例围生期和２例生后感染儿好转外，其余各例肝脏病变均已恢复。表明本组婴儿早期ＣＭＶ感染易累及肝脏，但肝损害多不重，预后较好。
To investigate the frequency and prognosis of liver damage caused by cytomegalovirus (CMV) infection, 47 infants born to CMVIgG-positive mothers were followed up within 1 week, 1 week, 3 months, 6 months and 12 months after birth. Anti-CMVIgM and IgG, urine CMVDNA (using in situ hybridization) and dynamic observation of liver lesions were detected by ELISA. Exclusion of biliary tract deformity, metabolic liver disease, drug-induced hepatitis and hepatitis A, B and C were observed. The results showed that 40 infants infected with CMV by the age of. Among them, 52.5% (21/40) had liver involvement. The incidence of liver damage in congenital and perinatal infections was 75.0% (18/24), which was significantly higher than that in postnatal infections (3l16, 18.8%), while no liver damage was found in uninfected children. In addition to 4 cases of dominant hepatitis, the performance of subclinical. Nearly half of cases (10/21) with splenomegaly. At the age of one year of follow-up in addition to 1 perinatal and 2 cases of postnatal infection improved, the rest of the cases of liver lesions have been restored. This group of infants showed early CMV infection easily affect the liver, but not more than the liver damage, the prognosis is good.