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用竞争性蛋白结合法和放射受体法观察了46例肾脏病患者血清维生素D代谢产物的变化。结果表明,各类肾脏病患者血清25-羟维生素D_3的含量均低于正常对照组,平均下降了41.2％(P<0.01),以尿毒症患者最低,表明肾脏病患者维生素D的营养状态是低下的。尿毒症和肾病综合征患者,血清1,25-二羟维生素D_3[1,25(OH)_2D_3]亦明显下降,分别比对照组降低了33.5％和42.4％(P<0.05),而慢性肾功能不全患者血清1,25(OH)_2D_3与肾功能不全的程度呈负相关。作者还对肾脏疾病维生素D代谢产物水平降低的机理进行了讨论。
The changes of serum vitamin D metabolites in 46 patients with renal disease were observed by competitive protein binding assay and radioactive receptor assay. The results showed that the levels of serum 25-hydroxyvitamin D3 in patients with various types of kidney disease were lower than those in the normal control group, with an average decrease of 41.2% (P <0.01) and the lowest in uremic patients, indicating that the nutritional status of vitamin D in patients with kidney disease was Low In patients with uremia and nephrotic syndrome, serum 1,25-dihydroxyvitamin D 3 [1,25 (OH) _2D_3] also decreased significantly by 33.5% and 42.4%, respectively, compared with the control group (P <0.05) Patients with dysfunction in serum 1,25 (OH) _2D_3 and renal insufficiency was negatively correlated. The authors also discuss the mechanisms underlying the reduced vitamin D metabolites in kidney disease.