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目的:研究桑椹补脑膏的镇静催眠作用。方法:将昆明小鼠随机分为空白对照组、地西泮片1.25 mg·kg-1组、桑椹补脑膏组(1.3、2.6、3.9 g·kg-1),连续灌胃给药14 d,通过小鼠自主活动试验、增强阈下剂量戊巴比妥钠诱导小鼠睡眠试验和协同戊巴比妥钠诱导小鼠睡眠潜伏期和睡眠时间试验,观察桑椹补脑膏的镇静催眠作用。结果:与空白对照组比较,桑椹补脑膏能明显减少小鼠自主活动次数,增加阈下剂量戊巴比妥钠小鼠的入睡率,缩短戊巴比妥钠小鼠的入睡潜伏期,延长其睡眠时间。结论:桑椹补脑膏对小鼠具有明显的镇静、催眠作用。
Objective: To study the sedative and hypnotic effects of mulberry nourishing and brain-clearing cream. Methods: Kunming mice were randomly divided into blank control group, diazepam tablets 1.25 mg · kg-1 group, mulberry buona group (1.3, 2.6, 3.9 g · kg-1) , Through the mouse autonomic activity test to enhance the subthreshold dose of pentobarbital sodium-induced mouse sleep test and pentobarbital sodium in mice induced by sleep latency and sleep time test to observe the sedative and hypnotic effects of mulberry Buzuo brain cream. Results: Compared with the blank control group, mongholiculine can significantly reduce the frequency of spontaneous activity in mice, increase the rate of falling asleep in the subthreshold dose of pentobarbital sodium mice and shorten the latency to fall asleep in pentobarbital sodium mice, sleeping time. Conclusion: Mulberry Bunao cream has obvious sedative and hypnotic effects on mice.