脉冲电场以其独特的生物电效应在肿瘤治疗等领域展示出良好的发展前景,并在国际上掀起了一股研究热潮。Weav-er等[1-2]发现在场强为1 kV/cm级、脉宽为100μs级的陡脉冲作用下,细胞膜出现微孔的同时电导率发生改变,当施加在细胞膜上的跨膜电位超过膜的绝缘强度时,电导率将激增,导致细胞膜阻碍微粒渗透能力降低,膜上出现亲水性孔道;当脉冲 Pulsed electric field shows its good prospect in the field of tumor treatment with its unique bioelectric effect, and it has set off an upsurge of research in the world. Weav-er et al. [1-2] found that under the action of steep pulses with a field strength of 1 kV / cm and a pulse width of 100 μs, the conductivity of the cell membrane changes while micropores are present. When applied to the membrane of the transmembrane Potential exceeds the dielectric strength of the membrane, the electrical conductivity will surge, resulting in cell membrane hinder the ability to reduce the penetration of particles, the membrane appears hydrophilic pores; when the pulse