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采用酶促培育法测定了８７例原发性肝癌病人血清醇脱氢酶（ｓＡＤＨ）活性，并与１７６例非肝病、非癌症病人、６６例正常人及７６例肝炎病人进行了比较，结果原发性肝癌病人ｓＡＤＨ活性显著高于非肝病、非癌症病人及正常人（Ｐ＜０．０１）；急、慢性肝炎病人ｓＡＤＨ活性也显著高于非肝病、非癌症病人及正常人（Ｐ＜０．０１）；非肝病、非癌症病人ｓＡＤＨ活性与正常人间无显著差异（Ｐ＞０．０５）。提示ｓＡＤＨ活性测定对于诊断原发性肝癌、肝炎具有器官特异性和疾病特异性。
The activity of serum alcohol dehydrogenase (sADH) in 87 patients with primary liver cancer was determined by enzymatic incubation and compared with 176 non-liver and non-cancer patients, 66 normal controls, and 76 patients with hepatitis. The activity of sADH in patients with hepatocellular carcinoma was significantly higher than that in non-liver diseases, non-cancer patients and normal persons (P<0.01). The sADH activity in patients with acute and chronic hepatitis was also significantly higher than that in non-liver diseases, non-cancer patients and normal persons (P<0. .01); sADH activity in non-hepatic and non-cancer patients was not significantly different from that in normal controls (P>0.05). It is suggested that the determination of sADH activity has organ specificity and disease specificity for the diagnosis of primary liver cancer and hepatitis.