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目的:观察非那雄胺联合维生素B2治疗良性前列腺增生症(BPH)的疗效。方法:选择老年BPH 100例,随机分为观察组和对照组各50例。对照组采用非那雄胺治疗,观察组采用非那雄胺联合维生素B2治疗。观察两组用药前和用药3个月、6个月及12个月后症状评分(IPSS)、最大尿流率、前列腺体积等变化情况。结果:治疗3个月后,观察组IPSS分值、最大尿流率均显著优于对照组(P<0.05);两组前列腺体积差异不显著(P>0.05)。6个月后,两组IPSS分值、最大尿流率及前列腺体积均差异不显著(P>0.05)。12个月后,两组IPSS分值、最大尿流率差异显著(P<0.05),前列腺体积差异不显著(P>0.05)。结论:非那雄胺联合维生素B2治疗BPH较单纯用非那雄胺疗效好。
Objective: To observe the efficacy of finasteride and vitamin B2 in the treatment of benign prostatic hyperplasia (BPH). Methods: One hundred elderly BPH patients were selected and randomly divided into observation group and control group with 50 cases each. The control group with finasteride treatment, the observation group with finasteride combined with vitamin B2 treatment. The changes of symptom score (IPSS), maximal uroflow rate and prostate volume before and 3 months, 6 months and 12 months after treatment were observed. Results: After 3 months of treatment, the IPSS score and the maximum uroflow rate in the observation group were significantly better than those in the control group (P <0.05). There was no significant difference in the prostate volume between the two groups (P> 0.05). After 6 months, there was no significant difference in IPSS score, maximum uroflow rate and prostate volume between the two groups (P> 0.05). After 12 months, there were significant differences in IPSS score and maximum uroflow rate between the two groups (P <0.05) and no significant difference in prostate volume (P> 0.05). Conclusion: Finasteride combined with vitamin B2 treatment of BPH is more effective than finasteride alone.