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临床实践中普遍使用内源性血清物质估算肾小球滤过率,血清肌酐浓度最为广泛的应用,然而,某些时候肌酐测量过高估计肾小球滤过率。半胱氨酸蛋白酶抑制剂C是一种低分子量的肾小球滤过率内在标志,大量研究证明它在体内产生速率稳定,影响因素极少,是反映早期肾小球滤过功能受损的一个更理想、更可靠的指标,并且众多数据表明半胱氨酸蛋白酶抑制剂C在指导很多心血管疾病的诊断及治疗中有潜在的临床意义。现综述提出微环境炎症可能是半胱氨酸蛋白酶抑制剂C、肾功能和心血管疾病之间的关联之处。
In clinical practice, the use of endogenous serum substances to estimate glomerular filtration rate, serum creatinine concentration of the most widely used, however, sometime creatinine measurement overestimates the glomerular filtration rate. Cystatin C is a low molecular weight intrinsic marker of glomerular filtration rate, a large number of studies have shown that its rate of stability in the body, with very few influencing factors, reflecting the early glomerular filtration dysfunction A more ideal, more reliable indicators, and a large number of data show that cystatin C has potential clinical significance in the diagnosis and treatment of many cardiovascular diseases. It is summarized that microenvironment inflammation may be the link between cystatin C, renal function and cardiovascular disease.