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自使用酮康唑治疗后,人们首先认识到唑类抗真菌药物可引起肝毒性.虽然也有报道氟康唑可引起肝毒性,但都未进行组织学检查证实.病人用氟康哇治疗出现肝功异常的问题尚不明确,因为交替使用的抗真菌剂如两性霉素B,也与产生肝毒性有关.在治疗病例中,有2例干氟康唑治疗期间出现一些符合肝炎的异常生化指标.但肝活检显示并无严重肝损害.查阅有关文献,氟康唑治疗中出现肝毒性的报道很少,故强调对出现肝功异常病人进行肝活检的重要性.
Since the use of ketoconazole treatment, people first realized that azole anti-fungal drugs can cause liver toxicity.Although it has also been reported that fluconazole can cause liver toxicity, but no histological examination confirmed that patients with fluconazole treatment of liver The problem of dysfunction is not clear because alternating antifungal agents such as amphotericin B are also associated with hepatotoxicity, and in the treatment cases there were 2 abnormal biochemical indicators that met hepatitis during the treatment of dry fluconazole .But the liver biopsy showed no serious liver damage.Read the literature, there is little report of hepatotoxicity in fluconazole treatment, it emphasizes the importance of liver biopsy in patients with liver dysfunction.