吗啉-2,5-二酮及其衍生物的开环聚合作为合成聚(乳酸-氨基酸)共聚物的主要方法,由于其单体繁琐的合成过程,较低的产率,使得合成共聚物的成本过高,极大限制了其在医药领域的广泛应用,为此,研究人员已经开始探索新的合成方法。对近几年来氨基酸与丙交酯的共聚和氨基酸与乳酸的直接熔融聚合的研究情况进行介绍。 Ring-opening polymerization of morpholine-2,5-dione and its derivatives As the main method for synthesizing poly (lactic acid-amino acid) copolymers, due to its cumbersome synthesis process and low yield, the synthesis of the copolymer The high cost, which greatly limits its wide application in the field of medicine, for which researchers have begun to explore new methods of synthesis. In recent years, the amino acid and lactide copolymerization and amino acid and lactic acid direct melt polymerization are introduced.