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目的 了解复方丹参注射液加胞二磷胆碱佐治新生儿缺氧缺血性脑 (HIE)的临床疗效。方法 将192例 HIE患儿随机分成治疗组及对照组。治疗组在基础治疗上加用复方丹参注射及胞二磷胆碱治疗。所有病例均采用新生儿行为神经测定法 (NBNA)于生后 12～ 14天接受 NBNA评估。结果 治疗组 ,预后正常为 12 2例 ,预后不良 6例 ;对照组 ,预后正常 4 5例 ,预后不良 19例。两组比较差异有显著性 (x2 =17.2 2 P<0 .0 0 1) ,治疗组疗效明显优于对照组。结果 HIE在基础治疗上再予复方丹参注射液及胞二磷胆碱辅佐治疗 ,能提高治愈率 ,降低伤残 ,值得临床推广。
Objective To investigate the clinical efficacy of compound Danshen injection plus citicoline in treating neonatal hypoxic-ischemic brain (HIE). Methods 192 cases of HIE were randomly divided into treatment group and control group. Treatment group in the basic treatment plus compound Salvia injection and citicoline treatment. Neonates Behavioral Nerve Detection (NBNA) was used in all cases to undergo NBNA assessment 12-14 days after birth. Results In the treatment group, the prognosis was normal in 12 2 cases and the prognosis was poor in 6 cases. In the control group, the prognosis was normal in 45 cases and the prognosis was poor in 19 cases. The difference between the two groups was significant (x2 = 17.2 2 P <0.001), the treatment group was significantly better than the control group. Results HIE in the basic treatment of compound Danshen injection and citicoline adjuvant therapy, can improve the cure rate, reduce disability, is worth clinical promotion.