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目的分析早产儿胃肠外营养并发胆汁淤积症的临床特点和预防措施。方法因黄疸原因收入消化科的患儿中诊治的胃肠外营养并发胆汁淤积症早产儿20例设为观察组,另选同期的20例采用胃肠外营养支持但没有发生胆汁淤积症的早产儿设为对照组,采用回顾性的方式分析患者的临床资料。结果研究结果表明,观察组患儿的平均胎龄(30.57±2.53)d、平均出生体重(1.31±0.23)kg,对照组患儿的平均胎龄(32.03±1.22)d、平均出生体重(1.51±0.24)kg,观察组患儿的平均胎龄和平均出生体重明显小于对照组(P<0.05);观察组患儿胃肠外营养持续时间(31.79±15.22)d、氨基酸最大剂量(2.62±0.35)g/(kg·d)、脂肪乳最大剂量(2.78±0.34)g/(kg·d),对照组患儿胃肠外营养持续时间(20.99±6.31)d、氨基酸最大剂量(2.02±0.29)g/(kg·d)、脂肪乳最大剂量为(2.01±0.37)g/(kg·d),两组数据结果比较差异有统计学意义(P<0.05)。结论胃肠外营养并发胆汁淤积症与出生体重低、胎龄小、胃肠外营养持续时间长、氨基酸的应用以及大剂量脂肪乳有着密切的关系。
Objective To analyze the clinical features and preventive measures of parenteral nutrition and cholestasis in premature infants. Methods 20 cases of preterm infants with parenteral nutrition complicated by cholestasis diagnosed and treated in children with digestive diseases due to jaundice were enrolled in the observation group. 20 cases of preterm infants with parenteral nutrition support but without cholestasis Children as a control group, a retrospective analysis of the clinical data of patients. Results The results showed that the average gestational age (30.57 ± 2.53) d, the average birth weight (1.31 ± 0.23) kg, the average gestational age (32.03 ± 1.22) days and the average birth weight ± 0.24) kg, the average gestational age and the average birth weight of the observation group were significantly less than those of the control group (P <0.05). The duration of parenteral nutrition (31.79 ± 15.22) d and the maximum dose of amino acids 0.35) g / (kg · d), the maximum dose of fat emulsion (2.78 ± 0.34) g / (kg · d), the duration of parenteral nutrition (20.99 ± 6.31) d and the maximum dose of amino acids 0.29) g / (kg · d), and the maximum dose of fat emulsion was (2.01 ± 0.37) g / (kg · d). There was significant difference between the two groups (P <0.05). Conclusions Parenteral nutrition complicated with cholestasis is closely related to low birth weight, small gestational age, prolonged parenteral nutrition, application of amino acids and high-fat emulsion.