目的:探讨药源性耳部不良反应的特点和预防方法,促进临床合理用药。方法:对国内各种期刊近10年来报道的药源性耳部不良反应进行统计分析。结果:引起药源性耳部不良反应的药物种类较多(60种药物),以氨基糖苷类抗生素为主(47.65%),其次是喹诺酮类(9.41%),大环内酯类(8.24%),氨基糖苷类抗生素引起的耳损害75.31%是不可逆的。结论:氨基糖苷类抗生素引起的耳鸣耳聋大多是不可逆的,临床上应慎用。 Objective: To explore the characteristics and preventive measures of drug-induced ear adverse reactions and to promote the rational use of drugs. Methods: Statistical analysis was made on the adverse reactions of drug-induced ear reported by various domestic journals in recent 10 years. Results: There were more drugs (60 kinds of drugs) causing side effects of drug-induced ear, mainly aminoglycoside antibiotics (47.65%), followed by quinolones (9.41%), macrolides (8.24% ), 75.31% of the ear damage caused by aminoglycoside antibiotics is irreversible. Conclusion: Most of tinnitus and deafness caused by aminoglycoside antibiotics are irreversible and should be used with caution in clinic.