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目的:探讨根除幽门螺旋杆菌(Hp)治疗前是否需停用质子泵抑制剂(PPI)。方法:随机将86例需要根除Hp的患者(治疗前已使用了质子泵抑制剂)分为治疗组和对照组,治疗组直接加用根除Hp的标准三联药物(奥美拉唑20mg/次,2次/日+克拉霉素500mg/次,2次/日+阿莫西林1000mg/次,2次/日),对照组停用质子泵抑制剂2周后再加用根除Hp的标准三联药物,疗程均7天,治疗结束后使用14C-尿素呼气试验评估Hp根治疗效。结果:治疗组和对照组Hp根除率分别为80.95%、84.09%,两组间比较差异无统计学意义(P>0.05)。结论:根除Hp治疗前无需停用质子泵抑制剂。
Objective: To investigate whether proton pump inhibitor (PPI) should be stopped before the treatment of Helicobacter pylori (Hp). Methods: Eighty-six patients who needed Hp eradication (proton pump inhibitor before treatment) were randomly divided into treatment group and control group. The treatment group was treated with standard triple therapy of eradication of Hp (omeprazole 20 mg / time, 2 times / day + clarithromycin 500mg / time, 2 times / day + amoxicillin 1000mg / times, 2 times / day), the control group after stopping the proton pump inhibitor for 2 weeks and then with the standard triple drug eradication Hp , The course of treatment was 7 days after the end of treatment using 14C-urea breath test to assess the efficacy of Hp radical. Results: The Hp eradication rates in the treatment group and the control group were 80.95% and 84.09% respectively, with no significant difference between the two groups (P> 0.05). Conclusion: Proton pump inhibitors need not be discontinued before eradication of Hp.