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目的 介绍NVB的严重神经毒性的发生 ,探讨其发生机理及处理措施。方法 通过回顾 3个典型病例进行分析。结果 3病例使用NVB后均出现了严重的神经毒性反应 ,主要表现为周围神经及消化道自主神经毒性 ,经积极处理后好转。其中 1例服用新药克痛宁后对缓解其周围神经痛效果良好。以后再次使用NVB时通过减少其剂量或延长前后 2次给药间隔 ,3例均未再出现上述严重反应。结论 NVB的严重神经毒性的发生与其剂量强度有关 ,克痛宁对缓解其周围神经痛有一定疗效 ,值得进一步探讨。
Objective To introduce the occurrence of severe neurotoxicity of NVB and to explore its mechanism of occurrence and treatment. Methods By reviewing three typical cases were analyzed. Results 3 cases of NVB after the emergence of a serious neurotoxic reaction, mainly for the peripheral nerve and gastrointestinal autonomic neurotoxicity, after the positive treatment improved. One case of taking a new drug Ketong Ning to relieve pain in peripheral nerves good effect. After re-use of NVB by reducing the dose or extend the interval before and after 2 doses, 3 cases were no longer the above serious reaction. Conclusion The serious neurotoxicity of NVB is related to the dose intensity of NVB. Ketongning has a certain curative effect on relieving peripheral nerve pain, which deserves further study.