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选取我院2013年1月~2014年4月收治的肝硬化患者75例,随机分为对照组和观察组。对照组患者入院后实施常规基础治疗,观察组患者在常规治疗基础上应用熊去氧胆酸。观察比较两组患者在肝功能指标变化、临床症状改善等方面的差异。观察组患者治疗后整体疗效优于对照组,总有效率达87.5%(35/40),对照组总有效率为68.6%(24/35),差异具有统计学意义(P<0.05);同时治疗2个月后观察组患者丙氨酸氨基转移酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)、直接胆红素(DBIL)等肝功能指标下降幅度大于对照组(P<0.05)。熊去氧胆酸联合常规基础治疗肝硬化疗效确切,可有效缓解临床症状,改善肝功能指标,加快患者康复,值得在临床上进一步推广。
Seventy patients with cirrhosis who were admitted to our hospital from January 2013 to April 2014 were randomly divided into control group and observation group. Patients in the control group received routine basic treatment after admission, and patients in the observation group received ursodeoxycholic acid on the basis of routine treatment. The differences between the two groups in the changes of liver function indexes and clinical symptoms were observed and compared. The total effective rate in observation group was 87.5% (35/40) after treatment. The total effective rate in control group was 68.6% (24/35), the difference was statistically significant (P <0.05) After 2 months of treatment, the decrease of hepatic function indices such as ALT, AST, TBIL and DBIL in the observation group was significantly lower than that in the control group (P <0.05). Ursodeoxycholic acid combined with the conventional basis for the treatment of liver cirrhosis is effective, can effectively alleviate clinical symptoms, improve liver function indicators, speed up the rehabilitation of patients, it is worth further promotion in the clinic.