肿瘤是一种细胞异常分化、增殖的疾病,其侵袭性的生长方式及转移要依赖于新生血管网的产生。事实上,早在1971年,Folkman就已经提出了肿瘤的生长依赖于新生血管的概念。后经试验证实,当肿瘤的体积小于2~3mm3时,肿瘤生长所需的营养物质均来源于其邻近的血供系统。而当瘤体大于2~3 Tumor is an abnormal cell differentiation and proliferation of diseases, and its invasive growth and metastasis depends on the production of neovascular network. In fact, as early as 1971, Folkman had proposed the concept that tumor growth depends on neovascularization. After the experiment confirmed that when the tumor volume is less than 2 ~ 3mm3, the nutrients required for tumor growth are derived from its neighboring blood supply system. And when the tumor is greater than 2 ~ 3