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目的 :探讨氧化镁、硝苯地平单独治疗和联合治疗轻、中度高血压病的疗效。方法 :采用随机单盲平行对照方式 ,172例高血压患者随机分为 3组 :氧化镁组 ;硝苯地平组 ;氧化镁 +硝苯地平组 ,疗程 8周。结果 :硝苯地平单独治疗或联用氧化镁治疗后均能显著降低血压 ,但两药联用治疗的总有效率 (91.1% )显著高于硝苯地平单用 (6 8.4% ) ,P <0 .0 1,氧化镁组治疗后血压无明显降低 (P >0 .0 5 ) ,总有效率 (5 .1% )显著低于硝苯地平组及两药联用组 (P <0 .0 1)。氧化镁组和两药联用组治疗后血清胆固醇明显下降 (P <0 .0 5 ) ;但血镁和其他生化检查改变不大。三组的不良反应均较少。结论 :氧化镁单独治疗无明显降压作用 ,但与硝苯地平联用时可使后者降压作用明显增强。
Objective: To investigate the curative effect of magnesia and nifedipine alone or in combination on mild to moderate hypertension. Methods: A randomized, single-blind, parallel-controlled trial of 172 hypertensive patients was randomly divided into three groups: magnesium oxide group, nifedipine group, magnesium oxide + nifedipine group for 8 weeks. Results: Nifedipine alone or in combination with magnesium oxide significantly reduced blood pressure, but the total effective rate (91.1%) was significantly higher than that of nifedipine alone (6 8.4%), P < (P> 0.05), the total effective rate (5.1%) was significantly lower than that of the nifedipine group and the combination of the two drugs (P <0. 01). 0 1). Magnesium oxide group and the combination of the two groups after treatment serum cholesterol decreased significantly (P <0.05), but blood magnesium and other biochemical tests changed little. Three groups of adverse reactions are less. Conclusion: There is no obvious antihypertensive effect in the treatment of magnesium oxide alone, but when combined with nifedipine, the antihypertensive effect of the latter can be obviously enhanced.