省级三家医院1987年住院确诊滋养性细胞疾病患者:良性葡萄胎30例,恶葡30例,绒癌20例,进行患者的病因和流行病学调查,对照组选自同期住院的正常产妇。病例组与对照组按1∶2配对.结果:单因素 Logisitic 回归模型分析方法,选出22个有相对意义的因子。多因素分析:年龄、孕早期使用激素史、丈夫初婚年龄、初潮年龄、怀孕次数、停房事天数等,有显著意义(P均<0.05或<0.01). Provincial hospital in 1987 diagnosed three patients with nosocomial trophoblastic disease: benign mole in 30 cases, 30 cases of malignant, choriocarcinoma in 20 cases, the etiology and epidemiological investigation of patients, the control group was selected from the same period of hospitalization of normal maternal. The case group and the control group were matched by 1: 2.Results: One-factor Logisitic regression model analysis method was used to select 22 relative factors. Multivariate analysis: age, gestational age in the first trimester, husband’s first marriage age, age at menarche, number of pregnancies, number of stay days, etc. were significant (all P <0.05 or <0.01).