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目的了解蚌埠地区乳腺癌的发病情况并分析其临床病理特点。方法回顾性分析446例乳腺癌病例的临床特点、肿瘤大小、病理分级、淋巴结转移、pTNM分期及部分病例雌、孕激素受体(ER、PR)、癌基因C-erbB-2表达情况。结果446例中女性占99.6%,平均年龄49.76岁,均以乳腺肿块为首发症状。自发现肿块至病理确诊平均时间11.58个月。肿瘤长径平均3.06cm。浸润性导管癌占92.8%,转移率58.8%,胸小肌外组和后组淋巴结转移率较高。ER阳性率45.3%,PR阳性率44.2%,C-erbB-2阳性率81.4%,C-erbB-2蛋白表达与ER、PR表达均有相关性。结论该地区乳腺癌多见于中老年妇女,早期发现率较低,就诊时均为浸润性癌,且半数已发生转移。开展乳腺癌普查对乳腺癌防治具有重要意义。
Objective To understand the incidence of breast cancer in Bengbu and analyze its clinicopathological features. Methods The clinical features, tumor size, pathological grade, lymph node metastasis, pTNM staging and expression of estrogen and progesterone receptor (ER, PR) and oncogene C-erbB-2 in 446 cases of breast cancer were retrospectively analyzed. Results 446 women accounted for 99.6% of the average age of 49.76 years old, were breast lumps as the first symptom. Since the discovery of the mass to the pathological diagnosis of the average time of 11.58 months. The average diameter of the tumor 3.06cm. Invasive ductal carcinoma accounted for 92.8%, the transfer rate of 58.8%, small extramandibular and post-group lymph node metastasis rate higher. ER positive rate 45.3%, PR positive rate 44.2%, C-erbB-2 positive rate 81.4%, C-erbB-2 protein expression and ER, PR expression are related. Conclusion Breast cancer is more common in middle-aged and elderly women in this area. The early detection rate is low. All the patients are invasive at the time of diagnosis, and half of them have metastasized. Breast cancer screening for breast cancer prevention and treatment is of great significance.