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对肝原性糖尿病18例,2型糖尿病22例及11例健康对照组行OGTT试验。结果:肝原性患者的IS低于对照组但好于2型糖尿病(P<0·05)。FPG与对照组无差异而PPG升高明显(P<0·01),但各点血糖均低于糖尿病患者(P<0·01)。存在高胰岛素血症与对照比P<0·05;与2型糖尿病比P<0·01。C肽的分泌与对照组比无差异。肝原性治疗所需的胰岛素剂量小于2型糖尿病(P<0·01)。结论:肝原性的糖代谢异常主要因素为胰岛素抵抗及肝脏的糖调节功能受损。
18 cases of hepatic diabetes, 22 cases of type 2 diabetes and 11 cases of healthy control group OGTT test. Results: The IS of hepatogenic patients was lower than that of the control group but better than that of type 2 diabetes (P <0.05). There was no difference between FPG and control group but PPG increased significantly (P <0.01), but the blood sugar of all the points were lower than that of diabetic patients (P <0.01). There was hyperinsulinemia compared with control P <0.05; and type 2 diabetes P <0.01. C peptide secretion and control group no difference. The insulin dose required for hepatogenicity is less than type 2 diabetes (P <0.01). Conclusion: The main factors of hepatic abnormal glucose metabolism are insulin resistance and impaired hepatic glucose regulation.