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分别用感染抗氯喹“NS”株小鼠血清(SMNS)、感染氯喹敏感株小鼠血(SMCS)和无原虫感染的正常小鼠血清(SM)与氯喹(CQ)水溶液的混合物治疗感染正常伯氏疟原虫小鼠。给药后5d涂片检查,SMNS+CQ组、SMCS+CQ组和SM+CQ组原虫感染率分别为:32、16和14％。SMNS+CQ组与其它两组原虫感染率比较,相差显著(P<0.05),提示SMNS对氯喹药效具有拮抗作用。进而发现当“NS”株对氯喹抗药性消失后,SMNS对氯喹药效的拮抗作用亦消失,另外,还同时测试了SMNS对氯喹、喹哌、羟基喹哌和
Infected with a mixture of anti-chloroquine “NS” mouse serum (SMNS), chloroquine-sensitive mouse serum (SMCS) and protozoal-free normal mouse serum (SM) and chloroquine Plasmodium ’s mice. At 5 days after administration, the prevalence of protozoal infections in SMNS + CQ, SMCS + CQ and SM + CQ groups was 32, 16 and 14%, respectively. SMNS + CQ group and the other two groups of protozoa infection rates, a significant difference (P <0.05), suggesting that SMNS antagonizes the chloroquine efficacy. Furthermore, it was found that the antagonistic effect of SMNS on the efficacy of chloroquine also disappeared when the resistance of the “NS” strain to chloroquine disappeared. In addition, the effects of SMNS on the activity of chloroquine, quipo,