论文部分内容阅读
AIM: To explore the mechanisms of uncut Roux-en-Y gastrojejunostomy, which is used to decrease the occurrence of Roux stasis syndrome.METHODS: The changes of myoelectric activity,mechanic motility and interstitial cells of Cajal (ICC) of the Roux limb after cut or uncut Roux-en-Y gastrojejunostomy were observed.RESULTS: When compared with the cut group, the amplitude (1.15 ± 0.15 mV vs 0.48 ± 0.06 mV, P ＜ 0.05)and frequency (14.4 ± 1.9 cpm vs 9.5 ± 1.1 cpm, P ＜0.01) of slow waves and the incidence (98.2% ± 10.4%vs 56.6% ± 6.4%, P ＜ 0.05) and amplitude (0.58 ± 0.08 mV vs 0.23 ± 0.06 mV, P ＜ 0.01) of spike potential of the Roux limb in the uncut group were significantly higher. The migrating myoelectric complexes (MMC)phase Ⅲ duration in the uncut group was significantly prolonged (6.5 ± 1.1 min vs 4.4 ± 0.8 min, P ＜ 0.05),while the MMC cycle obviously shortened (42.5 ± 6.8 vs 55.3 ± 8.2 min, P ＜ 0.05). Both gastric emptying rate (65.5% ± 7.9% vs 49.3% ± 6.8%, P ＜ 0.01) and intestinal impelling ratio (53.4% ± 7.4% vs 32.2% ± 5.4%, P ＜ 0.01) in the uncut group were significantly increased. The contractile force index of the isolated jejunal segment in the uncut group was significantly higher (36.8 ± 5.1 vs 15.3 ± 2.2, P ＜ 0.01), and the expression of c-kit mRNA was significantly increased in the uncut group (0.82 ± 0.11 vs 0.35 ± 0.06, P ＜ 0.01).CONCLUSION: Uncut Roux-en-Y gastrojejunostomy may lessen the effects of operation on myoelectric activity such as slow waves, spike potential, and MMC,decrease the impairment of gastrointestinal motility, and remarkably increase the expression of c-kit mRNA.