新生儿缺氧缺血性脑病(HIE)是引起新生儿急性死亡和慢性神经系统损伤的主要原因之一,而早期进行脑保护干预是防治HIE后遗症的重要手段之一,但在HIE临床特征及影像学改变出现之前,神经细胞的急性损伤已经发生。本研究通过测定HIE后不同时间血液中反应脑损伤的神经生化标记 Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the main causes of neonatal acute death and chronic nervous system damage. Early intervention of cerebral protection is one of the important measures to prevent and treat HIE sequelae. However, in the clinical features of HIE and Acute damage to nerve cells has taken place before imaging changes occur. In this study, we determined the neurobiochemical markers of reactive brain injury in blood at different times after HIE