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Paul Bert(1882)发现登高的动物产生低氧血症后,能通过血液中携氧能力增强来进行代偿。1940年以来Hurtards & Wilson等发现高山居民先天性紫绀型心脏病患者发生慢性缺氧后,能导致继发性红细胞增多和血浆容量增高。Dornhorst等把慢性阻塞性肺疾患(COPD)分成无绀气促型(Pink Puffer简称PP型)和紫绀臃肿型(Blue Bloated简称BB型)。BB型中某些患者由于慢性缺氧和二氧化碳潴留使红细胞增多,血容量、血液粘度增高加重肺循环
Paul Bert (1882) found that when an ascending animal produces hypoxemia, it compensates for the increased oxygen carrying capacity in the blood. Since 1940 Hurtards & Wilson found that chronic hypoxia in alpine congenital cyanotic heart disease causes secondary erythrocytosis and increased plasma volume. Dornhorst and other chronic obstructive pulmonary disease (COPD) is divided into non-cyanotic promoting type (Pink Puffer referred to as PP type) and cyanotic bloated (Blue Bloated referred to as BB type). Some patients with BB type because of chronic hypoxia and carbon dioxide retention of red blood cells, blood volume, increased blood viscosity aggravates pulmonary circulation