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长期以来,人们普遍认为细胞内外的水分子是以简单的跨膜扩散方式来通过脂质双层膜,但某些细胞如红细胞、肾近曲小管上皮细胞对渗透压引起的水通透性很高,很难单纯以简单扩散来解释。Agre(1991年)在研究红细胞膜上人类RH抗原时时意外发现水通道蛋白(Aquaporins,AQPs),Preston(1992年)等[1]先后完成对AQP1 DNA分子结构和功能鉴定,证明了该蛋白就是人们苦苦寻找的水通道蛋白,二者因此获得了2003
For a long time, it is generally believed that water molecules inside and outside the cell are transported through the lipid bilayer membrane in a simple transmembrane diffusion manner, but some cells such as erythrocytes and renal proximal tubule epithelial cells have very high water permeability to osmotic pressure High, it is difficult to simply explain the simple proliferation. Agre (1991) unexpectedly discovered Aquaporins (AQPs) when studying human RH antigens on erythrocyte membranes. Preston (1992) et al [1] completed the molecular structure and function identification of AQP1 DNA and confirmed that the protein was The aquaporins that people were struggling to find, both of which won the 2003